The Syrian Observatory for Human Rights - a UK-based activist network - said it was not clear what type of bomb was used, but that the force of the blast completely levelled the building.
"Only the night staff were on duty when the explosion occurred. If the bomb had gone off an hour before, there could have been up to 200 dead," the group's head, Rami Abdel Rahman, told Reuters news agency.
Below is a video of the explosion.
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